Poly(ADP-ribosylation) and neoplastic transformation:Effect of PARP inhibitors (Curr Pharm Biotechnol) - Mar 21, 2012 - PARP-1 & PARP-2 expression increases during neoplastic transformation, together with the basal levels of poly(ADP-ribosylation); Greater effect of the PARP inhibitor 3-aminobenzamide on cellular viability in neoplastically transformed cells
Preclinical-other • Oncology
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Curr Pharm Biotechnol. 2012 Mar 20. [Epub ahead of print]
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Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribosylation) play essential roles in several biological processes, among which neoplastic transformation and telomere maintenance. In this paper, we review the poly(ADP-ribosylation) process together with the highly appealing use of PARP inhibitors for the treatment of cancer. In addition, we report our results concerning poly(ADP-ribosylation) in a cellular model system for neoplastic transformation developed in our laboratory. Here we show that PARP-1 and PARP-2 expression increases during neoplastic transformation, together with the basal levels of poly(ADP-ribosylation). Furthermore, we demonstrate a greater effect of the PARP inhibitor 3-aminobenzamide (3AB) on cellular viability in neoplastically transformed cells compared to normal fibroblasts and we show that prolonged 3AB administration to tumorigenic cells causes a decrease in telomere length. Taken together, our data support an active involvement of poly(ADP-ribosylation) in neoplastic transformation and telomere length maintenance and confirm the relevant role of poly(ADP-ribosylation) inhibition for the treatment of cancer.
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